Berberine is a potent glucose-lowering supplement, with beneficial effects on lipid metabolism.
Studies show that treatment with Berberine improves insulin sensitivity and reduces blood glucose levels, either on its own or in combination with other glucose-lowering drugs in patients with diabetes. Berberine showed the greatest effect on body composition and lipid profile compared to other glucose-lowering drugs. Both total and LDL cholesterol decreased on Berberine. Berberine may therefore have greater potential to reduce the risk of cardiovascular disease than other glucose-lowering drugs.
The lipid-lowering effects of Berberine are comparable to those of conventional lipid-lowering drugs, but with low toxicity. Berberine suppresses cholesterol and triglyceride production and downregulates the development and accumulation of fat cells in the body.

Myo-Inositol is structurally similar to glucose – the body’s primary source of ATP, which provides cellular energy. It acts as a second messenger for several hormones and interacts with insulin, as well as the hormone that stimulates the thyroid (Thyroid Stimulating Hormone) and the hormone that stimulates ovulation (Follicle Stimulating Hormone).
Myo-Inositol and Metabolic Syndrome:
Metabolic syndrome includes a combination of high blood pressure, high blood sugar levels, excess body fat around the waist and abnormal cholesterol and triglyceride levels. The presence of metabolic syndrome increases a person’s risk of heart attack and stroke.
Myo-Inositol may help control metabolic risk factors by assisting in lowering blood triglyceride levels, cholesterol levels, blood pressure and blood sugar levels.
In studies, treatment with Myo-Inositol showed the same or greater improvement in blood glucose levels and insulin resistance, compared to other glucose-lowering drugs. Glucose and insulin levels were reduced and the insulin sensitivity of target tissues was improved. Continued treatment with Myo-Inositol resulted in significant weight loss.
In a year-long clinical study of 80 women with metabolic syndrome, 2 grams of inositol taken twice daily reduced blood triglyceride levels by an average of 34% and total cholesterol by 22%. Improvements in blood pressure and blood sugar were also seen. At the end of the study, 20% of the women no longer met the criteria for metabolic syndrome.
Myo-Inositol and PCOS:
Polycystic ovarian syndrome is an endocrine disorder that affects women of reproductive age and causes menstrual irregularities, infertility, hair loss and acne. Women with PCOS can present with insulin resistance, high blood sugar levels, unhealthy cholesterol, and triglyceride levels, as well as weight problems.
Insulin Resistance causes high levels of circulating insulin. Insulin has been shown in vitro to decrease the synthesis of SHBG. Low levels of sex hormone-binding globulin (SHBG) lead to increased levels of free testosterone, which prevent follicles in the ovaries from developing properly. This gives rise to menstrual abnormalities and infertility.
High levels of testosterone cause high levels of dihydrotestosterone, a metabolite of testosterone. High levels of dihydrotestosterone cause hair loss and increased sebum production by the sebaceous glands, leading to acne. Dihydrotestosterone also prolongs the anagen (growth) phase of hair growth, resulting in longer, thicker black facial and body hair.
Myo-Inositol works by reducing insulin resistance, thereby increasing levels of sex hormone-binding globulin (SHBG) and decreasing free testosterone levels. This improves the quality of the egg and the embryo and assists in restoring the menstrual cycle. Myo-Inositol supplementation reduces hair loss and improves acne.
Myo-Inositol increases insulin sensitivity, improves glucose and cholesterol levels, and assists with weight loss.
Myo-Inositol and Mental Health:
Myo-Inositol may assist in the treatment of depression, anxiety, and other mental illnesses by increasing the synthesis of serotonin and dopamine. Myo-Inositol supplementation helps reduce the frequency of panic attacks. It increases GABA levels and promotes sleep.

Chromium is an essential trace mineral that can improve insulin sensitivity and enhance protein, carbohydrate, and lipid metabolism. It regulates glucose levels, suppresses appetite, reduces cholesterol and assists with weight loss.